B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Hydroxychloroquine neuropathy Is hydroxychloroquine a time release pill Some changes in your nails are due to medical conditions that need attention. See your doctor if you have any of these symptoms discoloration dark streaks, white streaks, or changes in nail color Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Plaquenil nail changes Pincer nails in a patient with systemic lupus., Plaquenil Uses, Dosage & Side Effects - What is the mode of action of chloroquineHydroxychloroquine risk of ophthalmology On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. Hydroxychloroquine-Induced Retinal Toxicity - American.. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Plaquenil is supposed to help with hair loss, not contribute to it. I would also suggest giving it some more time especially since the side effects of plaquenil are supposed to lessen after a few months of use. I don't have a fungus, but I do have peeling nails. Never connected it to my lupus. The reddish puffy rashon your cheeks may be the lupus malar rash. Mine doesn't stay. It isn't every day, and now that I'm on plaquenil, I don't get it at all. Let us know what you learn. Nail changes a dermatologist should examine. Have you noticed a change to any of your nails lately? A change in color, texture, or shape can be harmless, but it can also be a sign of disease. If you notice any of the following changes to a fingernail or toenail, it’s time to see a board-certified dermatologist.