I'm not completely pain free, but it's a lot better than it was. I've been on plaquenil since mid June I have had a lot of stress in my life so I can't determine what is causing what. Not seeing any improvements with pain but I just went to 0 prednisone 3 weeks ago. said give it a few months and if I don't see any improvement I might as well go off of it. Wanted to let you know that I was on plaquenil for about three years and I told my RA doctor that my fatigue was worse. It just seems like the fatigue is worse than it has ever been, and it doesn't seem to matter if I go to bed early or take a nap during the day. Woke up and cleaned the kitchen an hour later(my kitchen is a galley kitchen 8 ft maybe.no time) Took a nap. Early on I did get those stomach cramps and diarrhea. All my pain is tolerable and he sees no deformities so he says he doesn't see RA activity. Just because the pain is tolerable doesn't make me like it any better. He did a plaquenil test and sure enough it was low. Chloroquine diphosphate in transfection Estradiol plaquenil combination Plaquenil and prednisone side effects Suicidal chloroquine poisoning Meds Celexa once a day, Buspar 2x a day, Levoxyl once a day, Metoprolol once a day, Lyrica 3x a day, Plaquenil 2 times day, Clonazepam to help me sleep for the moment until I find something else. Allergic to Sulfa, Ceftin, Augmentin, and Synthroid probably the filler. On plaquenil always made me feel very bad. hate it. before my diagnosis I was tired,aneamic,stiff etc since the plaquenil I jus flare all the time. it was so bad I just came off it for several months. got so ill they wanted me to go on chemo based drugs but I did not want that either. so reluctantly went back on the plaquenil. imo its made me worse. Some of the most common drugs that can make you tired are Allergy medications antihistamines, such as diphenhydramine, brompheniramine Bromfed, Dimetapp, hydroxyzine Vistaril, Atarax, and meclizine Antivert. Some of these antihistamines are in sleeping pills, too. Antidepressants. I wake up tired in the morning, get my kids fed and off to the schoolbus, and some days that's all I can do until it's time to go pick them up and make dinner, then I collapse after the kids are put to bed. I don't know if this is just the way RA is, or if it is a side effect of the medicine. Wasn't going to eat luch because I would have to move to do it.husband bought out. Kids came home, helped with homewrok, made dinner..picked up couch(because my blanket and pillow were there) Went to bed at 9. Does hydroxychloroquine make you sleepy Hydroxychloroquine - Side Effects, Dosage, Interactions., When starting hydroxychloroquine do symptoms feel. Plaquenil toxicity oct imagesOphthalmologic examination plaquenilChloroquine phosphate api manufacturers india Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. The United States Center for. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Medications That Can Cause Fatigue & Drowsiness. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Hydroxychloroquine is a good drug for mild arthritis however length of time it takes for drug to leave body is worrying when you are faced with loosing your sight and possible progression after you stopped taking the drug. Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD. It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms.