Chloroquine mechanism

Discussion in 'Northwest Pharmacy Canada' started by EFREYTER, 23-Feb-2020.

  1. SmiLie XenForo Moderator

    Chloroquine mechanism


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

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    The mechanisms of action of hydroxychloroquine and chloroquine remain under continuous study in modern molecular medicine 17,18 using advanced tools in computational biology 19, synthetic biology. Mechanism of action of chloroquine. Entry into the parasitized RBCs; 1. Accumulation in food vacuole of the parasite- role of pH gradient chloroquine trapping Affects asexual cycle of plasmodium specie. Once administered, it has to enter site of action. It rapidly enters and gets concentrated in food vacuole, present within erythrocytes. Two mechanisms are thought to be involved in chloroquine accumulation into the P. falciparum vacuole acidic trapping due to low vacuolar pH and chloroquine binding to heme or heme related species. It is reasonable to assume that PfCRT does not directly affect the molecular mechanism of chloroquine-HM binding.

    The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea.

    Chloroquine mechanism

    Chloroquine Mechanism of drug action and resistance in., Chloroquine – howMed

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  7. Mechanism Chloroquine phosphate is a 4-aminoquinoline compound for oral administration. Chloroquine is an antimalarial and amoebicidal drug. The drug possesses antimalarial actions and exerts a beneficial effect in lupus erythematosus chronic discoid or systemic and acute or chronic rheumatoid arthritis.

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    Apr 24, 2018 Learn about Chloroquine Mechanism of action and resistance in 2 minutes. Presenter Dr. Tanmay Mehta MD, DNB, PGDCTM The drug chloroquine is bactericidal for Bacillus megaterium ; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Inhibition of protein synthesis is also observed, evidently as a secondary effect. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen.

     
  8. LongInt Well-Known Member

    Rheumatoid arthritis treatment includes medications that slow the progression of joint damage from rheumatoid arthritis. Perioperative Management of Medications Used in the Treatment. Hydroxychloroquine Plaquenil Diagnosis and Management of Rheumatoid Arthritis - American.
     
  9. Sergick Well-Known Member

    Chloroquine & Hydroxychloroquine supporting chemo. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4.

    Chloroquine-induced interference with degradation of serum.