Chloroquine in lactation

Discussion in 'Northwest Pharmacy Canada' started by gorwok, 25-Feb-2020.

  1. Babalumba Moderator

    Chloroquine in lactation


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Breastfeeding. Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding. Drug Interactions. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Very small amounts of chloroquine are excreted in breast milk; when given once weekly, the amount of drug is not sufficient to harm the infant nor is the quantity sufficient to protect the child from malaria. United Kingdom malaria treatment guidelines recommend that weekly chloroquine 500 mg be given until breastfeeding is completed and primaquine can be given.1 Breastfeeding infants should. Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. Hydroxychloroquine is rapidly absorbed from the gastrointestinal tract, and steady-state concentrations are reached after 4–6 weeks; 45% of hydroxychloroquine binds to plasma proteins that are deposited in tissues such as the liver.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine in lactation

    Chloroquine - an overview ScienceDirect Topics, Chloroquine - Drugs and Lactation Database LactMed - NCBI.

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  4. Infants exposed to hydroxychloroquine during breastfeeding receive only small amounts of the drug in breastmilk. In infants up to at least 1 year of age, careful follow-up found no adverse effects on growth, vision or hearing.123 International experts indicate that hydroxychloroquine is acceptable during breastfeeding.4567

    • Hydroxychloroquine - Drugs and Lactation Database LactMed..
    • Hydroxychloroquine DermNet NZ.
    • Chloroquine - Uses, Dosage, Side Effects, Composition..

    If chloroquine should indeed inhibit the biosynthesis of sialic acid, this effect could explain not only the effects of chloroquine on HIV and SARS coronavirus sialic acid moieties are present in HIV-1 glycoproteins and SARS coronavirus receptor ACE2, but also the in-vitro effects on orthomyxoviruses which use sialic acid moieties as receptors Chloroquine crosses the placenta and is also found in low levels in breast milk, so pregnancy and lactation are often listed as contraindications to its use see DermNet NZ’s pages on Safety of medicines taken during pregnancy and on Lactation and the skin. However, effects on the fetus and baby have been rarely reported and chloroquine has been continued during pregnancy and lactation when required for malaria. Drug Safety in Lactation. Information on this subject has been updated. Read the most recent information. Prescriber Update 21 10- Sharon Gardiner, Drug Information Pharmacist, Christchurch Hospital and Evan Begg, Clinical Pharmacologist, Christchurch School of Medicine. Many mothers are required to use drugs during breastfeeding.

     
  5. Grifon User

    Interferes with digestive vacuole function within sensitive malarial parasites by increasing the p H and interfering with lysosomal degradation of hemoglobin; inhibits locomotion of neutrophils and chemotaxis of eosinophils; impairs complement-dependent antigen-antibody reactions Incomplete and variable (~70% [range: 25 to 100%]) (Tett 1993) Hepatic; metabolites include bidesethylchloroquine, desethylhydroxychloroquine, and desethylchloroquine (Mc Chesney 1966) Urine (15% to 25% [Tett 1993]; as metabolites and unchanged drug [up to 60%, Mc Chesney 1966]); may be enhanced by urinary acidification Rheumatic disease: May require several weeks to respond ~40 days (Tett 1993) ~40%, primarily albumin (Tett 1993) Lupus erythematosus: Treatment of chronic discoid erythematosus and systemic lupus erythematosus in adults. How to pronounce chloroquine How to pronounce Chloroquine Chloroquine Pronunciation. How to Pronounce chloroquine - American English - YouTube
     
  6. elitehoster Well-Known Member

    Plaquenil Oral Interactions with Other Medication Does Plaquenil Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more in.

    Plaquenil and Acetaminophen drug interactions - eHealthMe
     
  7. bigyalta Guest

    How to Succeed in Plaquenil Screenings Plaquenil hydroxychloroquine sulfate, Sanofi-Aventis and the less-used chloroquine are antimalarial drugs with anti-inflammatory properties that are used for the management of a spectrum of inflammatory conditions.

    Retinal Detachment in a Patient with Hydroxychloroquine Toxicity