Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid). Chloroquine phosphate overdose Order aralen prescribing Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. The molecular weight of hydroxychloroquine sulfate is 433.95, and molecular formula is C18H26ClN3O. H2SO4. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Both adults and children should take one dose of hydroxychloroquine per week starting at least 1 week. before traveling to the area where malaria transmission occurs. They should take one dose per week while there, and for 4 consecutive weeks after leaving. The weekly dosage for adults is 310mg base 400mg salt. It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015. Hydroxychloroquine weight based dosing RheumNow Hydroxychloroquine Blood Levels in SLE MedPage Today, PLAQUENIL® HYDROXYCHLOROQUINE SULFATE TABLETS, USP Lysosomotropic agent chloroquine whichDoes a daily dose if plaquenil help with joint pain Nov 25, 2019 Alternate dosing based on body weight A total dose representing 25 mg/kg is administered in 3 days, as follows First dose 10 mg base/kg not to exceed 620 mg base orally Second dose 5 mg base/kg not to exceed 310 mg base orally 6 hours after first dose Third dose 5 mg base/kg orally 18 hours after second dose Hydroxychloroquine Dosage Guide with Precautions -. Medicines for the Prevention of Malaria While Traveling.. Plaquenil hydroxychloroquine sulfate dosing, indications.. The current American Academy of Ophthalmology AAO guidelines, published in 2016, recommend a maximum daily hydroxychloroquine dose of ≤5.0 mg/kg of real weight. These guidelines were established to minimize the likelihood of permanent vision loss related to hydroxychloroquine retinopathy. Adherence to Weight-Based Dosing Guidelines in Patients Receiving Hydroxychloroquine for Rheumatoid Arthritis and Systemic Lupus Erythematosus Tara Skorupa 1 and Robert Shmerling 1, 1 Beth Israel Deaconess Medical Center / Harvard Medical School, Boston, MA Jan 03, 2020 Plaquenil Dosage Malaria. Adults 400 mg 310 mg base once weekly on the same day of each week starting 2 weeks prior. Lupus Erythematosus. The recommended adult dosage is 200 to 400 mg 155 to 310 mg base daily. Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may.