Chloroquine mode of action

Discussion in 'Hydroxychloroquine 200 Mg Tab' started by banshee(oleg), 17-Mar-2020.

  1. peter_850 New Member

    Chloroquine mode of action


    It is a rapidly acting drug, targeting the asexual stage. The mortality rate has increased along with the spread of malaria. p H of food vacuole of plasmodium specie is acidic while chloroquine is a weak base, leading to change in p H of food vacuole. More effective for long term treatment of rheumatoid arthritis as devoid of long term adverse drug reactions, especially eye changes. Use of chloroquine is declining recently due to the fact that most strains have become resistant. It rapidly enters and gets concentrated in food vacuole, present within erythrocytes. If we want to avoid relapse, Primaquine is used to eradicate tissue schizontal activity. Previously used for chemoprophylaxis, now due to development of resistance, chloroquine is not used. Anti-amoebic effect –infection caused by Entamoeba histolytica) Amebic liver abscess (as chloroquine is concentrated in the liver) because: Used for long time for rheumatoid arthritis, but because of associated ocular adverse effects, precaution is taken to have eye examination every 4 to 6 month to check retinal changes.

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    This finding, obtained without making any assumption on the nature of PfCRT, implies that hypothesis H2 is plausible, regardless of the chloroquine species involved in the chloroquineHM binding and of the mechanism of action of the mutated PfCRT. Consequently, none of the 20 cells C 1–5,1–4 can be shaded at this stage. Chloroquine's mode of action is not entirely clear -- however, it is possible that the drug stops the parasites from reproducing by interfering with their DNA. Click Chloroquine to learn more about the drug's mode of action. This article also tells you about possible side effects, safety warnings, dosing guidelines, and more. This represents a total dose of 2.5 g chloroquine phosphate or 1.5 g base in three days. The dosage for adults of low body weight and for infants and children should be determined as follows First dose 10 mg base per kg but not exceeding a single dose of 600 mg base.

    Plasmodium develops, multiplies and transforms by utilizing hemoglobin of human erythrocytes. Inhibits phospholipase A2 (used rheumatoid arthritis), chemotaxis is decreased, resulting in decreased proliferation of antigen. Primarily highly effective against febrile illness, relief is quickly achieved within 24 hours. CRTF Another gene involved is chloroquine resistance transporter factor (CRTF) 4. When administered, patient becomes afebrile within 24-48 hours. Resistance has developed in Afghanistan and Khyber Pathtunkhua.

    Chloroquine mode of action

    Effects of chloroquine on viral infections an old drug., Mode of Action of Chloroquine - Malaria Home Page

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  6. THE MECHANISM OF ACTION OF CHLOROQUINE There are almost as many different proposals to explain why chloroquine exerts a specific antimalarial activity as there are congeners of the parent compound synthesized in an attempt to improve its efficacy.

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    Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine. The drug chloroquine is bactericidal for Bacillus megaterium ; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Chloroquine inhibits the action of heme polymerase, which causes the buildup of toxic heme in Plasmodium species. 11 It has a long duration of action as the half life is 20-60 days. 10 Patients should be counselled regarding the risk of retinopathy with long term usage or high dosage, muscle weakness, and toxicity in children. 18. Mechanism of action

     
  7. sPavel Guest

    I don't know if anyone can help as this isn't technically lupus related. Healthboards - Immune & Autoimmune - Lupus tapering Plaquenil Hydroxychloroquine Oral Uses, Side Effects, Interactions. Had to stop taking Plaquenil -
     
  8. Flame New Member

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Drug-induced hyperpigmentation DermNet NZ Plaquenil and skin discoloration - Sjogren's World Hydroxychloroquine and skin darkening Hi All. - LUPUS UK
     
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