I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Treatment chloroquine resistant malaria Natural substitute for plaquenil So that's the update. The lesson here is - for those who need to go off plaquenil, be careful about just going off it cold turkey. Obviously some of CAN do that, but if you don't know if you're one of them - better to be on the safe side and wean slowly. Take it from me! I am feeling much better after bumping my dose back up over the last few. You can stop both meds abruptly if that is what you want - there is no need to wean. You should talk to your doctor first though. It is likely you will experience some form of pain and weaning at least your nabumetone may help to deal with this. I recently decided to stop taking Plaquenil because I was having constant chest pains even more so than I usually have due to Lupus. Since I have not taken it my chest feels so much better which is odd because chest pain is not listed as a side effect. Also I noticed that the Plaquenil I think was making me feel different but not in a good way. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. How to taper off of plaquenil Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, How do you wean yourself off of hydroxychloroquine? Hydroxychloroquine testingPlaquenil combination therapyHydroxychloroquine sulfate 200 mgManufacturer discount for hydroxychloroquine Hi everybody! I recently went to the doc and he recommended that I try cutting my Plaquenil in half from 400mg to 200mg/day. I have been on it since March, 2002. It's been about a week and I have noticed a few slight changes, mainly a little stiffness in my fingers and feeling a little fatigued. Healthboards - Immune & Autoimmune - Lupus tapering Plaquenil. Had to stop taking Plaquenil -. Steroid treatment for RA and advice for tapering. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory. It's ok to stop plaquenil without weaning, but I do recommend that if you feel you can wait til Monday, wait, and talk with your rheumy then. I felt that plaquenil wasn't helping, and was causing digestive problems for me, so with my dr. ok, I went off it. After two weeks off, I discovered it had been doing some good on the joint and muscle pain. Welcome to Sclero Forums! It is delightful to have you join us. I think your experience with going off plaquenil is very helpful for the rest of us to know about. You can let go of being angry at yourself, if you want. You didn't know for sure, ahead of time, that your health would worsen when you went off of plaquenil, did you?