Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine injection intravenous Hydroxychloroquine risk Joint pain after stopping plaquenil Many people try restricting either carbs or fat when trying to lose weight. This is a bad idea if your goal is to gain weight, as it will make it harder to get in enough calories. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. I have been on 400mg of Plaquenil since July of 2009 and it was increased to 600mg in October of 2010. I have not had any weight gain or increase in appetite. I have gained weight when I was not feeling well and was less active or when I was on high doses of prednisone. Best wishes Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Weiggt gain tryibg to get off plaquenil Plaquenil side effects - kidney problems? - Symptoms., What is the correct way to discontinue use of plaquenil? Plaquenil geneticHydroxychloroquine rheumatoid arthritis doseAntimalarial drugs chloroquine and primaquine Has anyone's doctor suggested taking plaquenil to help taper off Rheum thinks that plaquenil will help me get to a lower dose of prednisone since I can't get past 7.5 mg without a flare. Has anyone taken plaquenil to taper off prednisone.. Plaquenil and weight gain?. Insomnia because of plaquenil DailyStrength. Plaquenil is also an option for those who try and fail biologic drugs, cannot tolerate biologics or fear potential side effects linked to biologic DMARDs. How It Works Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. But what about when you go off of it? In case you’ve been thinking about it. Search. a third gain weight. these are all cues that some women look for if they're trying to get pregnant. I didn't have weight gain with either drug, but again thats just my own experience. I know both can be scary as they are powerful drugs, but they are manageable and in the right dosage can be very helpful to a better quality of life. I can't say for sure if plaquenil would slow down or halt progression of RA, but I've been told methotrexate does.