Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil and light sensitivity to eyes Lupus medicines hydroxychloroquine brigham For tamoxifen to do its job, it needs to be broken down in the body by a key protein known as CYP2D6. Unfortunately, many common medicines can block or slow down CYP2D6, and that would make tamoxifen less effective. Certain medications used to treat depression should be avoided by women taking tamoxifen. The study is based on hydroxychloroquine sulfate and ranitidine hydrochloride the active ingredients of Plaquenil and Ranitidine hydrochloride, respectively, and Plaquenil and Ranitidine hydrochloride the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered. I also am on plaquenil and have been for several years. Diagnosed with systemic scleroderma in 2002. I have developed pulmonary fibrosis in the lower lobe of my left lung last year and have PFT's done every 6months. Hydroxychloroquine may also be used for purposes not listed in this medication guide. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil and zantac Plaquenil Oral Uses, Side Effects, Interactions., Plaquenil and Ranitidine hydrochloride drug interactions. Plaquenil treatment chronic urticariaPlaquenil pyroderma Pariet and Zantac are acid inhibitors. Apparently Plaquenil does cause a lot of digestive problems for some people. However, I was prescribed Pariet prior to starting Plaquenil. I take a combination of Pariet and Endep.is to reduce acidity and give me relief from digestive nightmares. I get a good night's sleep. Ranitidine/otc zantac DailyStrength. Just Diagnosed with Crest Syndrome & Prescribed Plaquenil.. Plaquenil Oral Interactions with Other Medication. If you have psoriasis, chloroquine Aralen and hydroxychloroquine Plaquenil can cause problems. Other Medicines That Might Trigger a Flare. A few other drugs to discuss with your doctor include Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Drug interactions with ranitidine may occur when the medication is taken with warfarin, atazanavir, or itraconazole. Other medications that may interact with ranitidine include triazolam and ketoconazole. Drug interactions with ranitidine can affect the absorption of medicines into the body, which may result in reduced effectiveness of the.