It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Chloroquine warnings Macular degeneration from plaquenil Serious side effects. blurred vision or other vision changes. ringing in your ears or hearing loss. angioedema, or rapid swelling of your skin. hives. mild or severe bronchospasm that causes trouble breathing. sore throat. unusual bleeding or bruising. blue-black skin color. muscle weakness. hair. Side-effects aren't common. However, in some people hydroxychloroquine can cause skin rashes, especially those made worse by sunlight; feeling sick nausea or indigestion; diarrhoea; headaches; bleaching of the hair or mild hair loss; tinnitus ringing in the ears visual problems. Methotrexate vs plaquenil side effects long term and short term I was recently diagnosed with an autoimmune disease that mainly fuses my joints together, but causes severe pain and fatigue. The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Side effects of plaquenil and methotrexate Methotrexate Oral Route Side Effects - Mayo Clinic, Hydroxychloroquine Side-effects, uses, time to work Cyclosporine and plaquenilPlaquenil yeast infectionPlaquenil wbc Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Plaquenil Oral Uses, Side Effects, Interactions.. Methotrexate vs plaquenil side effects long term and short term. Common and Rare Side Effects for Methotrexate Anti-Rheumatic.. Call your doctor immediately or get emergency medical help if you experience any of the following serious side effects Any vision problems, such as reading difficulties, sensitivity to light, seeing light flashes or streaks, blurred distance vision, or other issues Hearing problems. We compare the side effects and drug effectiveness of Plaquenil and Methotrexate. The study is created by eHealthMe based on reports of 385,604 people who take Plaquenil and Methotrexate, and is updated regularly. eHealthMe has been monitoring drugs since 2008. Our original studies are referenced on 600+ peer-reviewed medical publications. Does anyone take methotrexate and hydroxychloroquine and has anyone had problems with hydroxychloroquine. Too many side effects of both methotrexate and Hydrochloroquine prompted my beautiful daughter to encourage me to go on a strict diet with no meds. I did check with my gp and rheumy re this.