Dark-skinned persons may experience generalized pruritus that is not indicative of drug allergy. Retinal toxicity that may occur with long-term high doses of chloroquine used in the treatment of other diseases is extremely unlikely with chloroquine given as a weekly malaria chemosuppressive agent. Plaquenil and lupus rash Plaquenil pregnan Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubated cultured parasites with subinhibitory doses of 3Hchloroquine and 3H quinidine. These 3Hquinoline compounds became associated with hemozoin. Original Article. The Molecular Basis of the Action of Chloroquine in Porphyria Cutanea Tarda. A single therapeutic dose of chloroquine, a 4 aminoquinoline, administered to patients with porphyria cutanea tarda PCT results in a massive porphvrinuria with subsequent remission at the disease. Apr 02, 2019 Mechanism of Action. Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo Because insufficient drug is excreted in breast milk to protect the infant, nursing infants should be given chloroquine. Chloroquine use is suitable for people of all ages and for pregnant women. Chloroquine method of action On the Mechanism of Chloroquine Resistance in Plasmodium., The Molecular Basis of the Action of Chloroquine in Porphyria. Hydroxychloroquine azithropine combinationCan you take hydroxychloroquine while pregnantChloroquine dosing for lupus retinaPlaquenil bladder infectionsWhat can i take for heartburn with plaquenil Summary. Aralen is the brand name for the generic drug chloroquine, an anti-malaria drug used to treat malaria and amebiasis infection that's spread outside of the intestines. Dosage, drug interactions, and pregnancy and breastfeeding safety information should be reviewed prior to taking this drug. Aralen chloroquine Malaria Drug Side Effects & Dosage. Aralen Chloroquine Uses, Dosage, Side Effects.. Chloroquine Indications, Side Effects, Warnings -. Dec 13, 2018 Each ACT is a combination of two or more drugs that work against the malaria parasite in different ways. Chloroquine phosphate. Chloroquine is the preferred treatment for any parasite that is sensitive to the drug. But in many parts of the world, the parasites that cause malaria are resistant to chloroquine. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. These compounds lead to improvement of clinical and laboratory parameters, but their slow onset of action distinguishes them from glucocorticoids and nonsteroidal antiinflammatory agents. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Fox RI1. Author information 1Department of Rheumatology, Scripps Clinic and Research Foundation, La Jolla, CA 92037. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus.