Chloroquine in early pregnancy

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  1. XenForo Moderator

    Chloroquine in early pregnancy

    This information should not take the place of medical care and advice from your healthcare providers. Hydroxychloroquine is a medication used to prevent and treat malaria and to treat autoimmune conditions such as rheumatoid arthritis or lupus.

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    Chloroquine, extensively used in pregnancy, is generally thought to be safe for mother and fetus at the therapeutically recommended dose.2 Treatment of Plasmodium falciparum malaria in pregnancy in Kenya3 and Tanzania 4 have indicated the drug to be safe, although with the problem of treatment failure because of parasite resistance. In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This is called her background risk. This sheet talks about whether exposure to hydroxychloroquine may increase the risk for birth defects over that background risk. Anti-malarial drugs hydroxychloroquine, chloroquine are considered pregnancy category C drugs. While there is evidence of risk for damage to the eye and ear, if the benefits of these drugs in controlling RA symptoms are judged to outweigh the risks, they may continue to be used during pregnancy. 1,2

    For more information on rheumatoid arthritis or lupus in pregnancy please see the Mother To Baby fact sheet on those topics at: or Hydroxychloroquine is sold under several brand names, including Plaquenil®.

    Chloroquine in early pregnancy

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  5. More research is therefore ideally required to confirm that use of chloroquine at this stage of pregnancy is not harmful. However, malaria infection during early pregnancy is itself known to increase the chance of miscarriage, and any possible risk from taking chloroquine is likely to be less than the risks posed to both mother and baby by malaria.

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    Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm. Currently, there are no viable treatment options to prevent the spread of ZIKV. However, in a study by Delvecchio et al. 2016, 17 the potential for the antimalarial agent chloroquine CQ to inhibit the endocytosis of ZIKV within human brain microvascular endothelial and neural stem cells was demonstrated in vitro. Pregnant women are advised to avoid travel to countries where there is elevated risk of contracting malaria. 2,3 For pregnant individuals who still choose to or must travel to malaria-endemic areas where there is chloroquine resistance, currently none of the available prophylactic drugs are recommended in early pregnancy.

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    Please make sure that Javascript and cookies are enabled on your browser and that you are not blocking them from loading. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. What Conditions does Plaquenil Treat? - WebMD Calcium channel blockers - Mayo Clinic
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  9. Lars_Ewlo New Member

    Chloroquine - Wikipedia Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. It is taken by mouth. Common side effects include muscle problems, loss of appetite, diarrhea, and skin rash. Serious

    Plaquenil Hydroxychloroquine - Side Effects, Dosage.