It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Pregnancy category hydroxychloroquine Sandoz plaquenil My question is for those that have taken Plaquenil/Hydroxychloroquine. How long did it take for it to remove symptoms in your personal experience? I know I've read it can take up to 6 months but what I'm wondering is, do you just wake up one day and find it's kicked in 6 months down the road or more likely, it starts to work slowly over 6 months? Hey everyone! Is anyone here with psoriatic arthritis just taking plaquenil or sulfasalazine or both together? I’m curious to know if these drugs can individually or mutually be enough to control inflammatory symptoms. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. What to use when plaquenil and sulfasalazine doesn't work Hydroxychloroquine Side-effects, uses, time to work, Any success with plaquenil or sulfasalazine? PsoriaticArthritis Benefits of using plaquenilHow does chloroquine workDefine chloroquine Taking plaquenil and sulfasalazine Arthritis Information. I was as scared as you are but my doc assured me that if it doesn't work for me we can switch to. Taking plaquenil and sulfasalazine Arthritis Information. Rheumatoid Arthritis Treatment Options Johns Hopkins.. PLAQUENIL" Rheumatoid Arthritis Community - Support Group. I was very gassy when starting out. It took me 6 weeks to go from 500mg per day to 2000mg. My symptoms were pretty severe in July 2018, and it took about 4 months for Plaquenil to do anything. At about 6 weeks on sulfasalazine, I started getting improvements. I'm now at 9 weeks and I went all day and barely had any joint pain. Hydroxychloroquine plaquenil and sulfasalazine azulfidine are used for mild rheumatoid arthritis. they are not as powerful as other dmards, but they usually cause fewer side effects. My mum was started on sulfasalazine 4 weeks ago for RA with severe bilateral hand pain and swelling. Initially everything was fine but when the dose was increased in the 2nd week to 500mg twice a day her mood started to deteriorate and developed symptoms of plantar fascitis.