Chloroquine resistance in plasmodium falciparum

Discussion in 'Canadian Pharcharmy' started by Keeps, 16-Mar-2020.

  1. Zam... XenForo Moderator

    Chloroquine resistance in plasmodium falciparum


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Abstract. The development of chloroquine as an antimalarial drug and the subsequent evolution of drug-resistant Plasmodium strains had major impacts on global public health in the 20th century. In P. falciparum the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in PfCRT, a protein that likely functions as a transporter in the parasite’s. Unfortunately, within a decade of its introduction, P. falciparum parasite resistance to chloroquine was observed in most of the malaria-endemic countries. Nowadays, insurgence of resistance against chloroquine is a considerable hurdle for malaria control 1. Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a multigenic basis of resistance.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine resistance in plasmodium falciparum

    CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM, On the Mechanism of Chloroquine Resistance in Plasmodium.

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  5. Despite its strategic location and importance, malaria epidemiology and molecular status of chloroquine resistance had not been well documented, and since chloroquine CQ, as the first-line treatment in Plasmodium falciparum infection was discontinued since 2008, it was expected that CQ-sensitive haplotype would be more abundant.

    • Epidemiology of malaria and chloroquine resistance in Mizoram..
    • Chloroquine Resistance in Plasmodium falciparum Malaria..
    • CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM MALARIA IN..

    Chloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than susceptible parasites, and this is thought to be the basis of their resistance. However, the reason for the lower accumulation of chloroquine was unknown. The resistant parasite has now been found to release chloroquine 40 to 50 times more rapidly than the susceptible parasite, although their initial. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy. The first confirmed cases of chloroquine-resistant Plasmodium falciparum acquired in Africa were reported in 1978 1 and occurred in non-immune travelers who had been in East Africa for relatively short periods of time.

     
  6. Tuzzic Guest

    VA CLASSIFICATION Primary: AP101 Secondary: MS109; TN900 Commonly used brand name(s): Aralen; Aralen HCl. Amoebic Liver Abscess by Dr. O. P. Kapoor Treatment of amoebiasis in adults and children. The treatment of hepatic amebiasis with chloroquine.
     
  7. vanvio Guest

    Norton Women's Specialists - Urogynecology, Louisville, KY Norton Women's Specialists - Urogynecology. A Medical Group Practice located in Louisville, KY

    Dr. Arthur Donovan, MD - Reviews - Louisville, KY
     
  8. Garik666 New Member

    PDF Genotypes and phenotypes of resistance in Ecuadorian. Conclusion This study indicates that Ecuadorian parasites presented the genotype and phenotype for chloroquine resistance and were found to be sensitive to SP, artemether-lumefantrine, quinine.

    CDC - Malaria - Malaria Worldwide - CDC's Global Malaria.