Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine sulfate drug class Lipusu liposome chloroquine Withdrawal symptoms of hydroxychloroquine Metoprolol and plaquenil interaction Plaquenil and small fiber neuropathy. I used Plaquenil years ago for extreme muscle and joint issues and it seemed to work fine. All my issues were resolved over a years time on low doses. I believe my problems started with side effects of a statin, which I stopped taking during my Plaquenil treatment but resumed after symptoms were resolved. Hydroxychloroquine sulfate is a colorless crystalline solid, soluble in water to at least 20 percent; chemically the drug is 2-4-7-Chloro-4-quinolylaminopentylethylamino ethanol sulfate 11. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. I have been taking Plaquenil along with Methotrexate for about 17 years for rheumatoid arthritis. Around 2009 I began experiencing the symptoms of peripheral neuropathy DADS with Mag1 antibody and tests later proved that I did, indeed have this affliction. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil neuropathy Will you have Peripheral neuropathy with Plaquenil - eHealthMe, Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Chloroquine lysosomal membrane permeabilizationDdo you have to stop plaquenil slowlyChloroquine tabletPlaquenil and uriStomach pain from plaquenil View detailed reports from patients taking plaquenil who experienced neuropathy peripheral. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. Hydroxychloroquine Sulfate Neuropathy Peripheral Reports.. Can Plaquenil cause Peripheral Neuropathy?. Common and Rare Side Effects for Plaquenil Oral. My understanding about Plaquenil is the doses taken for autoimmune disease is far less then that for Malaria, and even then the incident of neuropathy with malaria dosing is very low. Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1 Hydroxychloroquine is a well-tolerated antimalarial drug that can be effective for the cutaneous manifestations of DM. Evidence for the efficacy of hydroxychloroquine is limited.