Toxic retinopathy plaquenil

Discussion in 'Canada Pharmaceuticals Online' started by Makc_Rudy, 29-Feb-2020.

  1. Semm XenForo Moderator

    Toxic retinopathy plaquenil


    Plaquenil is less toxic than chloroquine; however, long-term use of either drug can result in macular toxicity, leading to devastating irreversible vision loss. The mechanism of this toxicity is not clearly understood, though it is believed that the drug molecule binds to melanin in the retinal pigment epithelium (RPE).

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    Plaquenil-induced toxic maculopathy was first described in 1967. Because the retinal damage from plaquenil is usually irreversible if present for a more prolonged period of time, it is important to detect the disease in its early stages. Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex. As the retinopathy progresses, a bull's-eye maculopathy develops, as seen in these. Jun 18, 2019 The classic sign of hydroxychloroquine retinopathy is bilateral “bull’s-eye” appearance of the macula due to disruption of the retinal pigmented epithelium. However, this finding occurs late in the toxicity and once it occurs the likelihood of permanent vision loss is significant so it is not useful as a screening tool. Medication Dosage

    Binding of the drug to melanin in the RPE contributes to, or prolongs, its toxic effects. This leads to disruption and damage to the photoreceptors and outer nuclear and plexiform layer, sparing the foveal center and resulting in the “bull’s eye” appearance in the late stage of the disease.

    Toxic retinopathy plaquenil

    Determine risk for hydroxychloroquine retinal toxicity., Bull's-eye maculopathy due to hydroxychloroquine toxicity

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  5. Plaquenil is less toxic than chloroquine; however, long-term use of either drug can result in macular toxicity, leading to devastating irreversible vision loss.

    • How to Succeed in Plaquenil Screenings.
    • Plaquenil Toxicity -.
    • Hydroxychloroquine toxicity - EyeWiki.

    Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. What You Should Know About Plaquenil Hydroxychloroquine Retinopathy. David J. Browning MD, PhD. Plaquenil generic name hydroxychloroquine is a drug developed in World War II as a prophylaxis and treatment for malariathat plagued allied soldiers in the Pacific theater.1 It worked well in that role, but as an unexpected side benefit, Jan 01, 2020 • Plaquenil is not effective against chloroquine or hydroxychloroquine-resistant strains of Plasmodium species see CLINICAL PHARMACOLOGY – Microbiology. Plaquenil is not recommended for the treatment of malaria acquired in geographic areas where chloroquine resistance occurs or when the Plasmodium species has not been identified.

     
  6. YuriyV XenForo Moderator

    Hi, I was diagnosed with RA and was put on sulfa, my rheumy tried adding mtx but i had awful side effects so am now on hydroxychloroquine and sulfa..this combination worked for anyone? Hi I've been on this combination for a few months and unfortunately it hasn't worked for me - but that's not to say it won't for you, we are all different in how we react to drugs. Sulphasalasine was helpful in my case but took 12 weeks to kick in. Hydroxychloroquine Side-effects, uses, time to work Effects of methotrexate and hydroxychloroquine combination. Does anyone take methotrexate and hydroxychloroquine. - NRAS
     
  7. Maxsimus Moderator

    Arava AND Plaquenil for RA. DailyStrength I was on Plaquenil and Arava, plus Orencia for a bit last year, till I finally went off the Plaquenil, which wasn't working. My enzymes went up a slight bit in the beginning and then settled down. It did not affect me nearly as badly as mthx. I was on that for 9 years, and my enzymes got so high I had to stop.

    Arthritis Medications and Hair Loss Arthritis Foundation