If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range (/= 6.5 mg/kg/day). This graph shows various formulas that have been proposed for deriving ideal body weight for women, because virtually all cases of hydroxychloroquine toxicity have been female. Chloroquine trade name generic name What is safe dosage of plaquenil for lupus A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a ppatient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. A total dose representing 25 mg of base per kg of body weight is administered in three days, as follows First dose 10 mg base per kg but not exceeding a single dose of 620 mg base. Second dose 5 mg base per kg but not exceeding a single dose of 310 mg base 6 hours after first dose. SAN FRANCISCO – Hydroxychloroquine Plaquenil dosing based on actual body weight – instead of ideal weight – is appropriate for patients with systemic lupus erythematosus SLE, according to a review of 686 lupus patients at Johns Hopkins University in Baltimore. Most were dosed by actual weight, 6.5 mg/kg up to a maximum of 400 mg/day. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. The usual hydroxychloroquine dose that is prescribed is 400 mg/day. Plaquenil dosing ideal body weight Hydroxychloroquine Blood Levels in SLE Clarifying dosing., DailyMed - PLAQUENIL- hydroxychloroquine sulfate tablet Chloroquine treatment of cellsHydroxychloroquine tablet cost Hydroxychloroquine Plaquenil Dosing Calculator. Ideal Body Weight and Adjusted Body Weight. Calculates ideal body weight Devine formula and adjusted body weight. IMDC International Metastatic RCC Database Consortium Risk Model for Metastatic Renal Cell Carcinoma. MDCalc - Medical calculators, equations, scores, and.. ACR Actual-weight hydroxychloroquine dosing works in SLE, up to a.. Despite Plaquenil dosing recommendations, retinal toxicity.. Initial dose 400 mg 310 mg base orally 1 to 2 times a day; this dose may be continued for several weeks or months, depending on patient response. Maintenance dose 200 to 400 mg 155 to 310 mg base orally daily. Comments -Each dose should be taken with a meal or a glass of milk. This patient clearly was not of ideal body weight, and, in my opinion, she was probably overdosed in relation to her ideal body weight. In 1983, Mackenzie 4 suggested that overdosage can be prevented if patients are prescribed a dosage that is based not on actual body weight, but on ideal lean body weight. Typical dose of antimalarial drugs may be too high since these drugs don’t accumulate in fat and bone1,13,14,19 Dosing for overweight and/or short individuals should be based on the basis of height, by finding an estimation of "ideal body weight" and not actual weight1,19 How to define if someone is overweight?