Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil 100 mg Plaquenil and dizziness Hydroxychloroquine is a 4-aminoquinoline in use for more than 30 years for the treatment of malaria, rheumatoid arthritis, and systemic lupus erythematosus. A recent study shows that the combination of MEK inhibitor trametinib and hydroxychloroquine led to a striking disease response in a patient with pancreatic cancer. This phase I trial studies the sides effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes, or other places in the body and cannot be removed by surgery. Correction The text describing a single-arm skin cancer study evaluating trametinib plus Novartis’s BRAF inhibitor dabrafenib with the addition of hydroxychloroquine for patients. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Trametinib hydroxychloroquine Reference ID 3315791, Trametinib and Hydroxychloroquine in Treating Patients with. How long do plaquenil side effects lastHow to make chloroquine poison Dabrafenib, Trametinib and Hydroxychloroquine in Patients With Advanced BRAF Mutant Melanoma BAMM The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Dabrafenib, Trametinib and Hydroxychloroquine in Patients.. Anticancer autophagy inhibitors attract ‘resurgent’ interest. Dabrafenib, Trametinib and Hydroxychloroquine in Patients With Advanced.. PLAQUENIL® HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION PLAQUENIL h. ydroxychloroquine sulfate is a. white or practically white, crystalline. powder freely. soluble in water; practically insoluble in alcohol, chloroform, and in ether. The. chemical. name for. Sometimes when dabrafenib and trametinib are given, the tumor cells activate a stress response called autophagy. Autophagy provides resistance to dabrafenib and trametinib treatment over time making them less effective. Giving hydroxychloroquine with dabrafenib and trametinib may reduce drug resistance and allow more tumor cells to be killed. Trametinib and Hydroxychloroquine in Treating Patients With Pancreatic Cancer THREAD The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government.